abstract：:Pyoderma gangrenosum (PG) is a rare, inflammatory, noninfective, nonneoplastic skin disorder, which is often associated with systemic diseases. These include inflammatory bowel disease, rheumatoid arthritis, paraproteinaemia, or hematologic malignancy, which can be found in up to 50% of patients with some variants of ...

journal_title：Clinics in dermatology

authors： Ahmadi S,Powell FC

更新日期：2005-11-01 00:00:00

abstract：:Hand dermatitis is a common diagnosis seen in dermatologic and general practice. It can present with typical morphology, but uncommon manifestations are possible. This review reports on common and uncommon presentations of irritant and allergic hand dermatitis focusing on uncommon localizations, time course, and morph...

journal_title：Clinics in dermatology

authors： Bauer A

更新日期：2005-09-01 00:00:00

abstract：:Human epidermis consists of a stratified epithelium mainly composed of keratinocytes and relies on a stem cell compartment to undergo constant regeneration. Genetic mutations affecting the capacity of basal keratinocytes to adhere firmly to the epidermal basement membrane lead to severe, and very often lethal, blister...

journal_title：Clinics in dermatology

authors： Ferrari S,Pellegrini G,Mavilio F,De Luca M

更新日期：2005-07-01 00:00:00

abstract：:Skin allografts were first used at the end of the last century by Girdner [Girdner JH. Skin grafting with graft taken from the dead subject. Med Rec (NY) 1881;20:119-20]; however, routine storage of human tissue developed only in the 1930s to 1940s [Webster JP. Refrigerated skin grafts. Ann Surg 1944;120:431-49] when ...

journal_title：Clinics in dermatology

authors： Pianigiani E,Ierardi F,Cherubini Di Simplicio F,Andreassi A

更新日期：2005-07-01 00:00:00

abstract：:Most mycobacteria cause localized and often harmless infections of the skin. Leprosy, which dates back to approximately 60 bc in India, was supposed to be eliminated as a public health problem by the year 2000. With a new case detection rate between 600,000 and 700,000 yearly however, leprosy, with its sometimes devas...

journal_title：Clinics in dermatology

authors： Faber WR

更新日期：2005-05-01 00:00:00

abstract：:Bites, stings and infestations can be fatal. Anaphylaxis to vespids and bees can be prevented with immunotherapy. Patients should be referred to an allergist. The acute care and prevention of arthropod injury is discussed below. ...

journal_title：Clinics in dermatology

authors： Elston DM

更新日期：2005-03-01 00:00:00

abstract：:More than 127 loci are actually known to affect pigmentation in mouse when they are mutated. From embryogenesis to transfer of melanin to the keratinocytes or melanocytes survival, any defect is able to alter the pigmentation process. Many gene mutations are now described, but the function of their product protein and...

journal_title：Clinics in dermatology

authors： Passeron T,Mantoux F,Ortonne JP

更新日期：2005-01-01 00:00:00

abstract：:Despite the development of laboratory methods, dermatological symptoms are a basic index of the presence and physical course of HIV infection. HIV infection usually undergoes a long latent period, proceeds to a period of immunodeficiency-related symptoms, and ends in an advanced immunodeficiency state characterized by...

journal_title：Clinics in dermatology

authors： Rigopoulos D,Paparizos V,Katsambas A

更新日期：2004-11-01 00:00:00

abstract：:Different physical treatments may be used in acne therapy. The main indications are for treating retentional lesions (open and comedones), inflamed lesions, and scars. ...

journal_title：Clinics in dermatology

authors： Dreno B

更新日期：2004-09-01 00:00:00

abstract：:An important feature in the etiology of acne is the presence of pilosebaceous ductal hypercornification, which can be seen histologically as microcomedones (Fig 1) and clinically as blackheads, whiteheads, and other forms of comedones, such as macrocomedones. There is a significant correlation between the severity of ...

journal_title：Clinics in dermatology

authors： Cunliffe WJ,Holland DB,Jeremy A

更新日期：2004-09-01 00:00:00

abstract：:Obesity is associated with a number of dermatoses. It affects cutaneous sensation, temperature regulation, foot shape, and vasculature. Acanthosis nigricans is the most common dermatological manifestation of obesity. Skin tags are more commonly associated with diabetes than with obesity. Obesity increases the incidenc...

journal_title：Clinics in dermatology

authors： Scheinfeld NS

更新日期：2004-07-01 00:00:00

abstract：:The introduction of sentinel lymph node biopsy (SLNB) has been an important development in the management of malignant melanoma. Lymph nodes have long been known to play a key role in melanoma metastasis. The importance of nodal staging accounted for the previous surgical practice of elective lymph node dissection (EL...

journal_title：Clinics in dermatology

authors： Lee KK,Vetto JT,Mehrany K,Swanson NA

更新日期：2004-05-01 00:00:00

abstract：:The cause and effect between ultraviolet light and cutaneous lupus erythematosus (CLE) is clear. In LE patients indeed, photosensitivity is one of the major diagnostic criteria of the systemic form of lupus erythematosus. This strong clinical association has led to the postulate that abnormal photosensitivity particip...

journal_title：Clinics in dermatology

authors： Angotti C

更新日期：2004-03-01 00:00:00

abstract：:Since the introduction of botulinum toxin (BTX) as a therapeutic tool in the 1970s, the number of uses for this substance has increased exponentially. BTX's mechanism of action involves degrading the SNARE proteins blockading the release of acetylcholine into the neuromuscular junction. In many body systems, decrease ...

journal_title：Clinics in dermatology

authors： Bentsianov B,Zalvan C,Blitzer A

更新日期：2004-01-01 00:00:00

abstract：:The ability of botulinum toxin A (BTX-A) to improve the appearance of facial lines was first reported among patients who had been receiving injections for facial dystonias or surgical procedures. Since that time, there has been very extensive use of this treatment for relaxation of a wide variety of facial muscles and...

journal_title：Clinics in dermatology

authors： Lowe NJ,Yamauchi P

更新日期：2004-01-01 00:00:00

abstract：:The recognition of botulinum toxin as a therapeutic tool has revolutionized the approach to facial esthetics. In the 1970s, Dr. Alan B. Scott pioneered the use of botulinum toxin type A (BTX-A) for strabismus. This discovery led to further studies examining other clinical applications of BTX-A and, more recently, botu...

journal_title：Clinics in dermatology

authors： Parish JL

更新日期：2003-11-01 00:00:00

abstract：:The recognition of medical benefits obtained with suberythemogenic doses of natural sunlight extends back centuries. Modern medical application of phototherapy has been in place for over 100 years. It is the nature of scientific discovery to depend upon the use of new investigational methods or new devices to gain a b...

journal_title：Clinics in dermatology

authors： Zanolli M

更新日期：2003-09-01 00:00:00

abstract：:The most extensive investigations of treatment of New World cutaneous leishmaniasis have been performed against L. panamensis disease in Colombia, and the relative value of regimens shown there may be instructive for disease from other areas. In Colombia, a 90-95% cure rate was achieved with three different drug regim...

journal_title：Clinics in dermatology

authors： Berman JD

更新日期：1996-09-01 00:00:00

abstract：:Most defects in dermatologic surgery can be repaired by primary closure. If this is not feasible, then local flaps should be employed. Where flaps are unfeasible or would result in an additional cosmetic deformity, then a full-thickness skin graft should be employed. If the defect is too large for a full-thickness ski...

journal_title：Clinics in dermatology

authors： Coleman W 3rd

更新日期：1987-10-01 00:00:00

abstract：:In summary, there is much overlap among the three types of localized cutaneous pemphigoid discussed. They all tend to affect the same age group, in general. They all may remain regional or be associated with a generalized eruption consistent with bullous pemphigoid. These three variants of subepidermal blistering dise...

journal_title：Clinics in dermatology

authors： Kaplan RP

更新日期：1987-01-01 00:00:00

abstract：:Human papillomaviruses (HPV) are clearly responsible for the induction of genital lesions like condylomata acuminata, bowenoid papules, and flat condylomas. Moreover, the DNA of particular virus types (HPV 16 and 18) is found in a substantial number of invasively growing squamous cell carcinomas of the genital tract, ...

journal_title：Clinics in dermatology

authors： Gissmann L,Gross G

更新日期：1985-10-01 00:00:00